Thesis

Street consensus, scenarios, merits, risks, and invalidation triggers

AI-assisted
Thesis Summary

Tempest Therapeutics is undergoing a major strategic pivot, shifting its primary focus toward next-generation dual-targeting CAR-T therapies (led by TPST-2003) acquired from Factor Bioscience in early 2026. While clinical data for both TPST-2003 (100% CR rate in early trials) and its Phase 3-ready HCC candidate amezalpat (TPST-1120) are highly promising, the company faces severe near-term financial and regulatory hurdles. With cash reserves down to $1.8 million as of March 31, 2026, an accumulated deficit of $270.1 million, and a Nasdaq deficiency notice regarding minimum stockholders' equity, Tempest is highly dependent on external funding commitments, warrant exercises, and securing strategic partnerships. A 'Hold' recommendation reflects the high-risk, high-reward nature of its clinical assets balanced against acute liquidity and delisting risks.

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This section is the 12-month view: analyst targets and the probability-weighted scenarios built from them. The intrinsic value at the top of this page answers a different question: what the business is worth today.
Street view · analyst 12-month targets1 analysts · as of 18 Aug 2026
Low · most bearish analyst$11.00
Mean target$11.00
High · most bullish analyst$11.00
Our research · scenarios, merits, risks, and invalidation triggersResearch as of 20 Jun 2026
Scenarios · 12-month scenario targetsAnchored at research date
Bear CaseDownside scenario

The company fails to regain compliance with Nasdaq's stockholders' equity or board independence requirements, leading to delisting to over-the-counter markets. Additionally, tight liquidity prevents the timely initiation of the TPST-2003 registrational trial, and the company is unable to secure a partner for amezalpat, forcing severe clinical delays or highly dilutive emergency equity financing.

Base CaseCentral scenario

The company successfully submits its Nasdaq compliance plan, utilizing recent warrant exercises (such as the $2 million gross proceeds in late May 2026) and the Factor Bioscience funding commitment to restore stockholders' equity above $2.5 million. TPST-2003 advances into a U.S. registrational Phase 2b study in late 2026, and the company secures a regional or global partner to fund the Phase 3 trial of amezalpat in HCC, alleviating direct cash burn.

Bull CaseUpside scenario

The strategic pivot into CAR-T therapy via the acquisition of TPST-2003 provides a validated clinical-stage asset with strong early efficacy (100% complete response rate in early trials) and extends the cash runway to mid-2027, while legacy assets like amezalpat remain Phase 3-ready pending strategic partnerships.

Scenarios are anchored to street consensus at the research date, with our probabilities and rationale.

Key Investment Merits
  • Strong clinical efficacy signal for TPST-2003, demonstrating a 100% complete response rate in early trials for relapsed/refractory multiple myeloma with a favorable safety profile.
  • Amezalpat (TPST-1120) is Phase 3-ready in first-line HCC with FDA Fast Track and Orphan Drug designations, showing a clinically meaningful 6-month improvement in median overall survival during Phase 1b/2 trials.
  • Capital-efficient development structure with multiple pipeline programs (including TPST-1495 in FAP) funded externally by partners like Novatim or institutions like the National Cancer Institute (NCI).
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Key Investment Risks
  • Severe liquidity constraints, with only $1.8 million in cash and cash equivalents as of March 31, 2026, and an explicit going concern warning.
  • Nasdaq delisting risk due to non-compliance with the $2.5 million minimum stockholders' equity requirement and board/committee independence rules.
  • High dependence on securing non-dilutive strategic partnerships or clinical collaborations to operationalize late-stage trials.
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Thesis Invalidation Triggers
  1. Receipt of a formal Nasdaq delisting determination if the compliance plan is rejected or if the company fails to meet equity thresholds by the deadline.
  2. Inability to secure a clinical partner or funding for the amezalpat Phase 3 trial within the next 12 months.
  3. Any safety signals or loss of efficacy depth in expanded clinical cohorts for TPST-2003.
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All scenarios are estimates and subject to change. Past performance is not indicative of future results.

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AI-assisted, source-linked narrative; figures from company filings (SEC EDGAR) and market data. Dates shown per section. Not investment advice. Terms of Use.